Hi everyone!
My name is Alissa and I've been sober from cocaine and heroine for almost 10 years since attending treatment/sober living. The treatment center and sober house I attended were on the other side of the US and I really through myself into the recovery community there. I was deeply involved in my home group. I took up every service opportunity I could. I can honestly say they were some of the best years of my life.
Well, fast forward 3 years and my mother was diagnosed with cancer. I moved back home to be close to my family and honestly, I never got fully plugged in to the AA community after moving. I started out going to meetings but it felt so different. And then I just stopped going. You guys know the drill. It didn't take long, but this insidious disease convinced me I could drink and smoke weed and that as long as I "stay away from the hard stuff" I would be fine. The issue is, I see the symptoms of my addiction permeating into all areas of my life. I'm having issues with my relationships with food. I'm a workaholic. I'm just overall not the happy, healthy person I used to be. I miss the commoradery I used to have in the rooms. I feel so isolated and alone. But I'm not sure how to take the first step and go back.
I'm married now and my husband seems to be in denial about my addiction. He didn't know me when I was at my worst and doesn't understand the dangers of how I'm living now. When I tell him I'm going to start going to AA again he gets very strange and beings questioning if I'm using heroin or coke behind his back. I know I need to just bite the bullet and get my ass into a meeting, I'm just having trouble taking the plunge.
TLDR - Relapsed on alcohol/weed after being clean for multiple years. Feeling like a fraud and having trouble getting back into the rooms.

Since it has many advantages over conventional open surgery, laparoscopic surgery, also known as minimally invasive surgery, has grown in popularity in recent years. With laparoscopy, a surgeon can view and operate on internal organs without making significant incisions by making small incisions in the abdomen through which a camera and surgical instruments are inserted.
The city of Varanasi in the Indian state of Uttar Pradesh is renowned for its top-notch medical facilities, which include laparoscopic surgery. One of the most popular forms of treatment for many different medical conditions in Varanasi is laparoscopic surgery. Aside from that, Varanasi is home to some of the best IVF clinics in the nation, which incorporate laparoscopic surgery into their infertility treatments.
In this blog, we will discuss everything you need to know about laparoscopic surgery in Varanasi, including the benefits of choosing laparoscopy, the availability of laparoscopic surgery, common laparoscopy treatments offered, and how laparoscopy is performed.
We will also discuss the role of laparoscopy in IVF treatment and the best IVF centers in Varanasi that offer laparoscopic surgery. By the end of this blog, you will have a better understanding of laparoscopic surgery in Varanasi and why it could be the right choice for you.
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Are you ready? Let’s get started!

Laparoscopic Surgery in Varanasi: An Overview

The way surgical procedures are carried out has changed thanks to laparoscopic surgery, also referred to as keyhole surgery or minimally invasive surgery. Small abdominal incisions are made during this procedure in order to insert a camera and surgical tools to view and access the internal organs. Traditional open surgery has many advantages over laparoscopy, including less pain, a shorter hospital stay, a quicker recovery, and less scarring.
Laparoscopic surgery is a popularly sought-after option in Varanasi for treating a variety of illnesses, including gynecological disorders, digestive disorders, hernias, and urinary tract disorders. The best results are guaranteed by the use of the most up-to-date technology and techniques by highly qualified and experienced laparoscopic surgeons in Varanasi.
Some of the best IVF clinics in the nation, which provide laparoscopic surgery as part of their infertility treatments, are located in Varanasi. Laparoscopy, which enables the surgeon to view the reproductive organs and spot any problems that might be causing infertility, is a crucial component of diagnosing and treating infertility.
Laparoscopic adhesiolysis, diagnostic laparoscopy, laparoscopic hysterectomy, laparoscopic myomectomy, and laparoscopic ovarian cystectomy are a few of the frequent laparoscopy procedures provided in Varanasi. Depending on the complexity of the procedure, the laparoscopic procedure in Varanasi is typically carried out under general anesthesia and can last anywhere from 30 minutes to a few hours.
If you are considering laparoscopic surgery in Varanasi, it is essential to choose the best laparoscopic surgeon and IVF center that meet your specific needs. The most qualified laparoscopic surgeons in Varanasi are highly skilled and experienced in performing laparoscopic surgery and use the latest technology and techniques to ensure the best possible outcomes.
Consequently, laparoscopic surgery is a secure and reliable option for treating a range of illnesses, including infertility. If you're considering laparoscopic surgery in Varanasi, be sure to select the top IVF clinic and laparoscopic surgeon to guarantee a positive outcome.

What are the benefits of Laparoscopic surgery?

Laparoscopic surgery, also referred to as minimally invasive surgery, is a type of surgery that makes small incisions in the body as opposed to large ones. Because it has so many advantages over conventional surgery, laparoscopy has grown in popularity recently.
Laparoscopy offers a number of advantages, such as less discomfort and scarring, shorter hospital stays, quicker recovery times, and a lower risk of complications. Laparoscopy has a lower risk of infection and less bleeding than open surgery because it is less invasive.
Laparoscopy is a flexible procedure that can be used for a variety of operations, such as cancer surgery, cyst and fibroid removal, and treatment for infertility. In comparison to traditional surgery, laparoscopy frequently allows patients to resume their regular activities faster and with less pain.
If you are considering laparoscopy, it's important to choose a skilled and experienced laparoscopic surgeon. The best IVF center in Varanasi may have a team of highly trained laparoscopic surgeons who can perform a range of procedures using this technique.

What are the common laparoscopy treatments offered and how is the treatment performed?

A laparoscope, a small, flexible tube with a camera and light at its tip, is used during minimally invasive surgery, or laparoscopic surgery. In the patient's abdomen, the surgeon makes a few tiny incisions and inserts the laparoscope, which sends images of the abdomen's interior to a monitor. This enables the surgeon to carry out various procedures without the need for a significant incision, leading to less discomfort, a quicker recovery, and a lower risk of complications.
Diagnostic laparoscopy for the diagnosis and treatment of conditions like endometriosis, ectopic pregnancy, and ovarian cysts are common laparoscopic procedures. Hysterectomy, myomectomy, tubal ligation, and the management of uterine fibroids are also performed using laparoscopic surgery. Both male and female infertility can be identified and treated using laparoscopy.
The surgeon may use forceps, scissors, and probes among other tools during the laparoscopy procedure to carry out the surgery. In order to give the surgeon more room to work, the abdomen is frequently inflated using carbon dioxide gas.
Usually, general anesthesia is used during laparoscopy, and patients can go home the same day or the day after the procedure. Patients frequently experience less pain and scarring, and recovery times are typically shorter than with traditional open surgery.

Role of laparoscopy in IVF treatment

The laparoscopy procedure is essential to the success of IVF. It is used to identify and treat a number of conditions, including endometriosis, blocked fallopian tubes, and ovarian cysts, which can affect fertility. To remove any barriers and raise the possibility of a successful IVF procedure, laparoscopic surgery is performed.
Laparoscopy is typically performed during an IVF cycle as a day procedure, allowing the patient to go home the same day. A small camera is inserted through a very small abdominal incision during the laparoscopy procedure for IVF treatment. The surgeon can closely inspect the pelvic area thanks to the camera's ability to send images to a monitor.
To obtain eggs for IVF treatment, laparoscopy is another option. The eggs are removed from the ovary during this procedure, called laparoscopic egg retrieval, using a tiny needle that is inserted through the laparoscope.
Selecting a qualified and skilled laparoscopic surgeon who can carry out the procedure safely and effectively is essential if you intend to receive IVF treatment. The most effective IVF facilities in Varanasi have skilled laparoscopic surgeons who use the latest technology and techniques to ensure the best possible outcome for their patients.

Conclusion

Laparoscopic surgery, a minimally invasive procedure, has gained popularity for the diagnosis and treatment of a variety of gynecological conditions. It offers numerous advantages over traditional open surgery, including less pain, faster recovery times, and smaller incisions.
IVF New Life is the best IVF center in Varanasi, that offers laparoscopy treatment with advanced technology and skilled laparoscopic surgeons. The center has a team of experienced doctors who specialize in laparoscopy treatment, providing high-quality care to patients with gynecological conditions.
With their state-of-the-art facilities and personalized care, IVF New Life is an ideal choice for anyone looking for laparoscopy treatment in Varanasi. So, if you are in need of laparoscopic surgery, contact IVF New Life today to schedule a consultation with one of their expert laparoscopic surgeons.

Greetings all, Firstly, I'm new to this sub and would like to express my appreciation for the help provided to others. It is very noble indeed. 56 y/o male, 6' 2", 200 lbs, caucasian. Pmhx of GERD, BPH, HLD, former smoker (quit 10 yrs ago). Looking for opinions from radiation oncologists or others knowledgeable of types of radiation therapy. I have buccal/gingival SCC and had surgery April 13th to include left partial maxillectomy and MRND with 36 lymph nodes removed. Path report shows clean margins (closest 5mm) but positive PNI, LVI, and a tiny bit of ENE so the plan is for concurrent chemo (cisplatin) and radiation. I may have a choice between proton or IMRT. I am seeing two rad/onc providers, one local for IMRT in case proton is denied, and another at a cancer center where surgery was performed that offers proton therapy. The IMRT is ready to start ...the proton therapy is still mired in insurance hurdles (Requesting peer to peer discussion but initially denied). My question is, are the benefits of PBT worth the drive, logistics, and possible delay in treatment, worth waiting for the chance of approval? Thanks for any help or insight.

Biotechnology Stocks

Lexicon Pharmaceuticals

• The Trade: Lexicon Pharmaceuticals, Inc. LXRX 10% owner Invus Advisors Llc acquired a total of 27,775,050 shares at an average price of $2.60. Acquire these shares, it cost around $72.22 million.
• What’s Happening: Lexicon Pharmaceuticals announced the pricing of a $125 million public offering and concurrent private placement.
• What Lexicon Pharmaceuticals Does: Lexicon Pharmaceuticals Inc is a biopharmaceutical company. It is engaged in the discovery, development, and commercialization of pharmaceutical products for the treatment of human diseases.

Heliogen

• The Trade: Heliogen, Inc. 10% owner Patrick Soonshiong acquired a total of 180,012 shares at an average price of $0.25. The insider spent around $44.16 thousand to buy those shares.
• What’s Happening: Heliogen posted a narrower-than-expected quarterly loss.
• What Heliogen Does: Heliogen Inc is a concentrated solar energy system that is being developed to unlock the power of sunlight to replace fossil fuels.

ImmunityBio

• The Trade: ImmunityBio, Inc. Director Michael Blaszyk acquired a total of 71,915 shares at an average price of $2.75. To acquire these shares, cost around $198.02 thousand. The company’s other Directors also purchased the company’s shares.
• What’s Happening: ImmunityBio announced it received a complete response letter from the FDA on May 9th regarding its BLA for Anktiva in combination with Bacillus Calmette-Guérin.
• What ImmunityBio Does: ImmunityBio Inc is a late-clinical-stage immunotherapy company developing next-generation therapies that drive immunogenic mechanisms for defeating cancers and infectious diseases.

Fintech Stocks

OLB

• The Trade: In the last 100 trades there were 911.09 thousand shares bought and 678.34 thousand shares sold. The last trade was made 175 days ago by Ernst Ehud who sold 500 shares. The large amount of stocks bought compared to stocks sold indicates that the insiders believe there is a potential good upside.
• What’s Happening: Revenue increased by 80% between 2021 and 2022, but its valuation is low compared to SHOP and BIGC. It is entering a huge market to serve customers without bank accounts.
• What The OLB Group, Inc. Does: provides integrated financial and transaction processing services for small and mid-sized merchants in the United States. It is also involved in cryptocurrency mining activities; cryptocurrency-related services; and the provision of e-commerce development and consulting services

RIOT

• The Trade: Soo Yi, the Executive Chairman recently netted about US$9.0m selling shares at an average price of US$11.87. That's a big disposal, and it decreased their holding size by 21%, which is notable but not too bad.
• What’s Happening: Riot ended the month of May with approximately 800 miners staged for deployment. Upon deployment of the staged miners, the Company expects to have a total of 94,976 miners deployed with a hash rate capacity of approximately 10.6 EH/s
• What Riot Platforms, Inc., Does: together with its subsidiaries, operates as a Bitcoin mining company in North America. It operates through Bitcoin Mining, Data Center Hosting, and Engineering segments. The company also provides co-location services for institutional-scale bitcoin mining companies, and critical infrastructure and workforce for institutional-scale miners to deploy and operate their miner

NPR investigation reveals the growing influence of the far right and their efforts to dismantle the Electronic Registration Information Center (ERIC).
Starting point: The far-right website Gateway Pundit initiated discussions on ERIC in January 2022, which led to a campaign against the voter fraud prevention tool. * A week later, Louisiana became the first state to withdraw from ERIC, citing concerns from citizens, government watchdogs, and media reports.
Local groups' involvement: NPR found that local "election integrity" groups played a significant role in the effort to discredit ERIC across the country. * Groups like Protect Your Vote Florida launched campaigns to influence state legislators to suspend their contracts with ERIC.
Trump ally's coordination: Cleta Mitchell, known for working with Trump to overturn the 2020 election, has been a ringleader in the effort to dismantle ERIC. * Mitchell hosted a secret ERIC summit with red state lawmakers last summer and has started an Election Integrity Network.
Impact on elections: With states withdrawing from ERIC, voter rolls may be less accurate leading to longer lines at precincts and mail ballots being sent to incorrect addresses.
View original article on NPR
This summary was created by an AI system. The use of this summary is subject to our Terms of Service.

(Remember in all this there almost 100% blind)
Now this will be multiple posts as i can’t put out the amount of info i want too in just one
What i talk about in each part (only 2 of them) so you can see if your interested in any:
Part one
(I’m using this as -/- the left side is the part and the right side is what i’m referring to the claim)
1/1 Division Of Labor - Roles (Queen, soldiers, workers) - Caste system/Hierarchy - A second caste system in workers
1/2 Cooperative care: - Roles - Babysitting - Training and socialization - Nursing and grooming - Tending to weak.
2/1 Communication: - How they communicate - Each family having there own accents - Tactile signals - Chemical signals
2/2 Aspects of biology: - Having evolved an insanely strong cancer resistance - Living to 30 yrs when rodent sized usually die after 2-4 yrs. - Ability to survive with very low oxygen.
(Whichever number is in the title is the part)
2/1 Communication:
Dialects: Naked mole rats exhibit dialects, where different colonies or family groups have distinct vocalizations and scent profiles. These dialects arise from unique environmental conditions, social interactions, and genetic factors within each colony. The dialects help naked mole rats recognize and differentiate between individuals from their own colony and individuals from neighboring colonies.
Vocalizations: Naked mole rats produce a range of vocalizations to convey information. These vocalizations include chirps, trills, squeaks, and low-frequency calls. Each type of vocalization can carry different meanings, such as signaling danger, indicating mating readiness, or coordinating group activities.
Tactile signals:Naked mole rats also use tactile communication extensively. They have sensitive whiskers and use them to interact and communicate with each other. For example, they engage in nose-to-nose touching, which is a common behavior during social interactions and helps to establish social bonds and convey messages.
Chemical communication: Scent plays a crucial role in naked mole rat communication. They have scent glands located on various parts of their bodies, particularly around their faces. These glands produce specific chemical signals that convey information about individual identity, reproductive status, and social hierarchy. By detecting and interpreting these chemical cues, naked mole rats can distinguish between colony members and outsiders and establish territorial boundaries.
2/2 Aspects of Genetic Biology:
High cancer resistance do to evolving with things like:
• HMM-HA: High-molecular-mass hyaluronan inhibits cell proliferation and promotes tissue integrity, contributing to cancer resistance.
• Contact inhibition: Naked mole rat cells halt division upon contact, preventing uncontrolled growth and the formation and spread of tumors.
• DNA repair: Naked mole rats have highly efficient DNA repair mechanisms that rapidly identify and correct DNA damage, reducing the risk of mutations and cancer development.
• Tumor-suppressing genes: Naked mole rats possess additional tumor-suppressing genes, such as p16, which control cell division and prevent tumor formation, enhancing their resistance to cancer.
Long Lives: (Smaller animals very commonly have faster metabolisms which a species metabolism is how to determine lifespan and how we perceive time)
• Low metabolic rate: Naked mole rats have a relatively low metabolic rate, which reduces the production of harmful byproducts and slows down aging processes. This is because the underground environment lacks abundant oxygen, and naked mole rats have adapted to thrive in low-oxygen conditions i go into next.
• Enhanced oxidative stress resistance: They possess higher levels of antioxidants and increased activity of antioxidant enzymes, protecting against oxidative damage and extending lifespan.
• Efficient DNA repair mechanisms: Rapid identification and correction of DNA damage help maintain genetic integrity and minimize age-related decline.
• Cellular maintenance and protein stability: Effective cellular processes, such as autophagy and protein quality control, preserve cellular health and prevent the accumulation of damaged molecules.
• Insensitivity to age-related conditions: Naked mole rats exhibit resistance to age-related diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
Ability to Survive With Low Oxygen intake: • Underground habitat: Naked mole rats adapted to low-oxygen underground burrows, necessitating efficient oxygen utilization.
• Anaerobic metabolism: They can switch to anaerobic metabolism to generate energy without relying on oxygen.
• Oxygen efficiency: Optimized respiratory and circulatory systems allow effective oxygen uptake and distribution

https://scitechdaily.com/stanford-medicine-reveals-tiny-dna-circles-defying-genetic-laws-drive-cancer-formation/ Stanford Medicine-led researchers have found that tiny circles of DNA known as extrachromosomal DNA (ecDNA) play a significant role in cancer formation. These circles contain oncogenes and can exist in large numbers within cells, providing a potent growth signal that overrides normal cellular programming. The study revealed that ecDNA can be present even in precancerous cells and initiates the development of cancer. Understanding and targeting ecDNA formation could potentially prevent cancer development and improve early diagnosis.

https://scitechdaily.com/stanford-medicine-reveals-tiny-dna-circles-defying-genetic-laws-drive-cancer-formation/ Stanford Medicine-led researchers have found that tiny circles of DNA known as extrachromosomal DNA (ecDNA) play a significant role in cancer formation. These circles contain oncogenes and can exist in large numbers within cells, providing a potent growth signal that overrides normal cellular programming. The study revealed that ecDNA can be present even in precancerous cells and initiates the development of cancer. Understanding and targeting ecDNA formation could potentially prevent cancer development and improve early diagnosis.

Introduction: Ensuring the health and well-being of our children is of utmost importance, and when it comes to their vision, it becomes even more critical. Children require specialized care to address their unique eye health needs. In Ghatkopar, Mumbai, parents can find solace in the expertise and dedication of Dr. Jatin Ashar at his renowned Pediatric Eye Care Clinic. With a passion for pediatric ophthalmology and a commitment to providing comprehensive eye care, Dr. Ashar has become a trusted name in the field. Let's delve deeper into the exceptional services and compassionate approach offered at this esteemed clinic.
Unraveling the Pediatric Eye Care Clinic: Situated in the heart of Ghatkopar, the Pediatric Eye Care Clinic is a state-of-the-art facility equipped with the latest technology and a child-friendly environment. Dr. Jatin Ashar, a distinguished pediatric ophthalmologist, leads the clinic, bringing years of experience and expertise to benefit his young patients.
The expertise of Dr. Jatin Ashar: Dr. Jatin Ashar is a prominent figure in pediatric ophthalmology, known for his compassionate approach and commitment to excellence. His exceptional credentials and extensive knowledge have made him a sought-after professional in the domain. Dr. Ashar completed his medical education at reputed institutions and pursued specialized training in pediatric ophthalmology. He has worked with numerous children, addressing various eye conditions and providing practical solutions tailored to their unique needs.
Eye Specialist In Ghatkopar Dr. Jatin Ashar Director and Chief Operating SurgeonMD (AIIMS), DNB, FICO (UK), FAICO & a fellow of L V Prasad Eye Institute Cataract, Cornea, and Refractive surgery specialist Soft-spoken, compassionate, and an intellectual man, Dr. Ashar trained at the prestigious ‘All India Institute of Medical Sciences’, New Delhi; one of Asia’s best! After his post-graduation, he completed his fellowship in Cornea and Anterior Segment from the world-renowned L. V. Prasad Eye Institute. Later on, he was appointed as the main cornea consultant at the ‘New Tertiary Care Center’ at the same institute. Our remarkable sensitivity to patient's needs and providing the warmth of compassionate healing make us stand apart. Technology is mandatory for high standards of care and Mumbai Eye Care understands that. We use only the latest technology and best-in-class equipment throughout the hospital.
Comprehensive Pediatric Eye Care: At the Pediatric Eye Care Clinic, Dr. Jatin Ashar and his dedicated team offer a wide range of services to ensure optimal eye health for children. They specialize in the diagnosis, treatment, and management of various eye conditions affecting infants, children, and adolescents. Some of the key services provided at the clinic include:

1. Comprehensive Eye Examinations: Dr. Ashar conducts thorough eye examinations to assess visual acuity, eye movement, and overall eye health. These examinations help identify refractive errors, amblyopia (lazy eye), strabismus (crossed or misaligned eyes), and other ocular abnormalities.
2. Vision Correction: The clinic offers a range of corrective measures, including prescription glasses and contact lenses, to address refractive errors like nearsightedness, farsightedness, and astigmatism. Dr. Ashar ensures that the vision correction options provided are comfortable, safe, and tailored to each child's needs.
3. Treatment of Eye Conditions: Dr. Jatin Ashar specializes in the diagnosis and treatment of various eye conditions, such as amblyopia, strabismus, pediatric cataracts, congenital glaucoma, and genetic eye disorders. He adopts a multidisciplinary approach, combining the latest medical advancements with personalized care.
4. Eye Muscle Surgery: When necessary, Dr. Ashar performs eye muscle surgery to correct strabismus, improving the alignment of the eyes and restoring binocular vision. These surgical interventions are conducted with utmost precision and care to achieve optimal outcomes.
5. Parental Guidance and Counseling: Dr. Ashar understands the importance of parental involvement in the care of their children's eyes. He provides guidance and counseling to parents, educating them about common eye conditions, preventive measures, and strategies to promote good eye health in children.

Child-Centric Approach: Dr. Jatin Ashar and his team prioritize creating a warm and child-friendly environment at the clinic. They understand that visiting a doctor can be intimidating for young patients, so they go the extra mile to ensure a comfortable experience. The clinic is designed to engage children and ease their anxiety, with colorful décor, interactive toys, and friendly staff who are adept at handling children of all ages.
Conclusion: Dr. Jatin Ashar's Pediatric Eye Care Clinic in Ghatkopar stands as a beacon of hope for parents seeking exceptional eye care for their children. Driven by a passion for pediatric ophthalmology and armed with extensive knowledge and expertise, Dr. Ashar offers comprehensive eye care services that address the unique needs of young patients. With a child-centric approach and a commitment to excellence, Dr. Ashar and his team are dedicated to safeguarding and enhancing the precious gift of sight in children.
Name: Mumbai Eye Care Address: 101/102, Sai Vaibhav CHS, Nr. Vikrant Circle, Ghatkopar (East), Mumbai-400077 Phone: +91-8451045934, 8451045935, 022-25066699 Website: www.mumbaieyecare.com Website: www.mumbaieyecarecornealasik.com

Physiotherapy center Calgary NW is staffed by trained and licensed physiotherapists who are experts in the diagnosis, treatment, and prevention of physical injuries and conditions. These healthcare professionals work with patients of all ages and abilities, from athletes recovering from sports injuries to seniors dealing with arthritis and other age-related conditions.

When it comes to eye health, particularly in preventing age-related macular degeneration (AMD), the Age-Related Eye Disease Study (AREDS) and its successor, AREDS2, have made significant contributions to our understanding of dietary supplementation for eye health. That being said, the AREDS formulas aren't without their share of controversy, especially concerning the dosage of zinc.

Rethinking Zinc in the AREDS Formulas

The original AREDS formula contains 80 mg of zinc oxide, a level that has been criticized as being excessive. The AREDS2 study, responding to concerns about the potential toxicity of higher zinc levels, reduced the amount of zinc to 40 mg. While follow-up research showed that 40 mg of zinc is a better dose than 80 mg, the question of whether 25 or 30 mg (total) would be equally as effective, but safer, remains unanswered. It is suggested that a dose of 30 mg may be as effective for most people and likely safer.
Another concern around the AREDS study involves the simultaneous intake of multivitamins by study participants. In AREDS, two-thirds of participants took multivitamins along with the AREDS formulation, and in AREDS2, this number was almost nine out of ten. Given that multivitamins often contain additional zinc, this introduces potential variability in total zinc intake, complicating the analysis of the study results.

Building a Case for Full-Spectrum Carotenoids

Both AREDS formulas include carotenoids, but their usage of isolated forms has provoked criticism. The first AREDS formula contained β-carotene, which was removed in AREDS2 due to increased lung cancer risk among smokers consuming it in its isolated form. (This risk was not observed with food-based carotenoids.) Despite the elimination of β-carotene, the use of other isolated carotenoids in the AREDS formulas remains controversial.
I assert that carotenoids, as they naturally occur together in many fruits and vegetables, should be consumed in a full-spectrum approach to maximize their health benefits and ensure safety.
Interestingly, high β-carotene intake from foods does not increase lung cancer risk, even in smokers, whereas isolated β-carotene does. This contrast could arise due to a disproportional intake of β-carotene compared to other carotenoids like β-cryptoxanthin, or that high intake of β-carotene may prevent the absorption of other carotenoids. This competition for absorption is exemplified by evidence showing that higher intakes of lutein and zeaxanthin can decrease β-carotene absorption (van Het Hof et al., 2000).
Moreover, the role of β-cryptoxanthin, another dietary carotenoid, highlights the safety of the full spectrum approach. A study showed high dietary intake of β-cryptoxanthin is associated with a lower risk of lung disease in smokers, contrasting with the effects of isolated β-carotene (PubMed 36771049). People who consume more β-carotene from food automatically obtain more of the other carotenoids, including β-cryptoxanthin.
Further supporting the advantages of the full spectrum approach, recent studies show lycopene, a carotenoid not found in the macula but rich in tomatoes, may protect lutein and zeaxanthin en route to the macula (Antioxidants 2020, 9, 264; Antioxidants 2019, 8, x). This research implies that protection against AMD could extend beyond lutein and zeaxanthin supplementation and towards a broader dietary carotenoid intake.
Another carotenoid source worth noting is the golden spice, saffron. Saffron is a rich source of many carotenoids, but two are particularly relevant to AMD: crocin and crocetin. Clinical research indicates that daily supplementation with 30 mg of saffron for six months can significantly improve retinal function in patients with AMD (PMID: 28289690).
There are over 600 carotenoids that naturally occur in foods, each with potentially unique and beneficial properties. This rich diversity further supports the need for a full-spectrum carotenoid approach in both our diets and supplementation practices.
Studies tend to focus on isolated nutrients. The reason is not that isolated nutrients are superior, but rather than conducting studies and analyzing results is easier. Therefore, we don't have many studies looking at the advantages of the "full spectrum" approach, but it is a conservative approach that could potentially offer more benefits and fewer risks. The idea is based on the premise that in nature, nutrients typically work synergistically, providing more significant health benefits when consumed together than individually.

Where Do We Go from Here?

Despite their drawbacks, the AREDS and AREDS2 supplements remain some of the most widely recommended in ophthalmology practices. These formulas have significantly advanced our understanding of nutritional intervention for eye health. However, like all areas of medical science, there's always room for improvement and refinement.
The concerns around zinc dosage and carotenoid selection in the AREDS formulas highlight the need for continued research and improved formulas. As we strive for improved eye health, we must continue to explore and refine these formulas, keeping up with new scientific discoveries and the evolving understanding of nutritional science.
There's a growing consensus favoring a full-spectrum approach to carotenoids over isolated forms. The complexity and diversity of carotenoids in nature seem to hint at a sophistication that we are just beginning to comprehend.
The ultimate goal of these efforts is to create a supplement that is maximally effective, yet closer to nature. While we may not be there yet, my research is focused on formulating the next generation of supplements that reflects the complexity and richness of nature itself.
In the meantime, if you are taking the AREDS formula with 80mg of zinc, consider switching to something else. The AREDS2 formula is a better choice due to the reduced amount of zinc, but the dose remains high enough that, at a minimum, most of us should avoid simultaneously consuming other supplements that contain zinc.
Another consideration is the consumption of isolated carotenoids. If you are consuming any isolated carotenoids, take care to ensure that you also consume plenty of "full spectrum" carotenoids from foods and, optionally, from a concentrated natural carotene source such as saffron or some of the herbs and spices listed below:

• Parsley: It contains a variety of carotenoids, including β-carotene, lutein, and zeaxanthin.
  
• Basil: Both sweet and holy varieties of basil are rich in β-carotene, lutein, and zeaxanthin.
  
• Saffron: As mentioned above, saffron contains two carotenoids important to eye health, crocin and crocetin, which give it its vibrant color.
  
• Coriander: Coriander, also known as cilantro, is rich in β-carotene, lutein, and zeaxanthin.
  
• Chili Powder: Chili powder contains a variety of carotenoids, including lutein, zeaxanthin, and β-carotene.
  
• Paprika: Paprika is made from ground bell peppers and is a good source of β-carotene and other carotenoids.
  
• Rosemary: It contains carotenoids including β-carotene, lutein, and zeaxanthin.
  
• Tarragon: This herb is another good source of β-carotene.
  
• Oregano: It also contains carotenoids, including β-carotene.
  
• Marigold: Marigold (specifically the species Tagetes erecta) is rich in lutein and zeaxanthin and is commonly used to produce lutein supplements.
  
• Cayenne Pepper: Cayenne pepper contains carotenoids, including capsanthin, capsorubin, and β-carotene.
  
• Dill, Parsley, and Thyme: These are good sources of carotenoids, especially β-carotene.
  
• Peppermint: Peppermint contains β-carotene among other carotenoids.
  
• Sage: This herb is known to contain carotenoids, including β-carotene and lutein.
  

These herbs and spices should complement a balanced and varied diet rich in fruits and vegetables. Furthermore, you can leverage knowledge from traditional medical systems, such as Ayurveda and TCM, to fine-tune your personal selection of healing herbs and spices.
Always remember to check the latest research for the most accurate information.

The Central Board of Direct Taxes (CBDT) introduced the new income tax e-portal at "www.incometax.gov.in" with effect from June 7, 2021. This website, which took the role of the outdated platform "www.incometaxindiaefiling.gov.in," was updated to make it simpler to access services for ITR filing, tax payments, and other matters pertaining to taxes. Let's examine the main functions of this new portal in more detail and explain how to use the new Income Tax website to make your self-assessment tax payment online.
The New Income Tax e-Portal's Features and Benefits
The new income tax portal not only makes ITR filing simpler but also provides a lot of helpful features for taxpayers. Here is a sneak peek at some of these features and advantages available on the new tax filing platform.

• Streamlining the processing of income tax returns to expedite refunds
• Free ITR-2 (available online), ITR-1, and ITR-4 (available both online and offline) ITR preparation software
• A brand-new integrated call center service for prompt response and issue resolution
• A more straightforward interface that is nevertheless comprehensive to make it easier to retrieve prior ITRs and pending activities
• Pre-filled ITR help reduce errors and speed up income tax return filing

On the New Income Tax e-Portal, How Do You Pay Your Self-Assessment Tax?
After deducting tax deducted at source (TDS), tax collected at source (TCS), and advance tax payments, you still have to pay self-assessment tax. On the income tax e-portal itself, you can pay your self-assessment tax quickly and conveniently, both before and after logging into your account.
Self-Assessment Tax Payment Without Using the e-Filing Portal
To pay your taxes online, you can use the pre-login service. Here is a step-by-step manual to assist you in finishing this procedure.
Step 1: Go to http://www.incometax.gov.in/e-Filing and select the 'e-Pay Tax' link.
Step 2: input and verify your PAN on the following page, then input your registered cellphone number.
Step 3: Next, input the OTP that was issued to your registered number and select "Continue."
Step 4: The website will reveal your PAN and name. Verify these specifics then move forward.
Step 5: Following that, you will see various tax payment categories. On the category that deals with self-assessment tax, click "Proceed."
Step 6: Next, choose the applicable minor head for the assessment year for which you are making the tax payment and press the "Continue" button.
Step 7: On the following page, you can list the various components of the tax that must be paid, such as the tax, surcharge, cess, interest, penalty, and other items.
Step 8: After that, you will be taken to a new page where you may choose the payment method that works best for you. Choose from alternatives including RTGS/NEFT, debit cards, net banking, and payment portals.
Step 9: You will see a preview of the tax breakdown after selecting your preferred payment method. Verify this information, then select "Pay Now."
Step 10: Read the terms and conditions, accept them, and then continue to pay the tax online.
After logging into the electronic filing portal, paying the self-assessment tax
You can use the income tax e-portal's post-login function to pay your self-assessment tax as well. What you need to do is as follows.
Step 1: Enter your user ID and password to access the income tax e-Filing system.
Step 2: Hover your cursor over the "e-File" menu options on the homepage dashboard and select "e-Pay Tax" from the dropdown list that displays.
Step 3: The website will take you to the 'e-Pay Tax' page, where you must choose to make a new payment by clicking the '+ New Payment' button.
Step 4: Subsequently, you will notice various tax payment categories. Select the category that applies to self-assessment tax, then continue.
Step 5: Before choosing "Continue," choose the pertinent evaluation year and the pertinent minor head.
Step 6: Submit the specifics of how the tax is broken up (including tax, cess, surcharge, interest, and penalties, for example).
Step 7: Next, pick a suitable payment method from a list that includes RTGS/NEFT, debit cards, net banking, and payment portals.
Step 8: After that, you'll see a sneak peek of the tax breakdown. Verify the information and select "Pay Now."
Step 9: Read the terms and conditions, agree to them, and pay the tax online.
Conclusion:
As you can see above, paying your self-assessment tax via the new income tax e-Filing system is very straightforward. To prevent interest and penalties for late tax payments, make sure to calculate any taxes due and pay them promptly. Additionally, you can only file your income tax returns after paying all the taxes that are owed. Therefore, you must make your self-assessment tax payment on time in order to finish completing your ITR before the deadline.

I have some big news about the future of The Brotherhood of Old. I'm mostly writing this as a commitment to myself so that I actually do it, and also as a rallying call to those who may be interested in helping out. Feel free to read along as I think aloud. This will be a long read, so buckle up.
I have decided to cancel development of version 1.2 and shift my focus to developing version 2.0. This will obviously push any updates outside of 2023.
What is version 2.0?
As stated in the previous announcement for version 1.2:

My main objective is to completely remake and restructure the final few quests, mainly "The Cults of Darkness" and "The True Brotherhood" as these are the most complicated and complex quests in the mod and often have issues running properly.

That will no longer be the main focus. What I aim to accomplish with version 2.0 is something I've been wanting to do for many years but have not had the time to do until recently... So now you're probably saying "Come on man, get to the point!" So, without further ado:
Version 2.0 at its core, will be a complete rework of the entire mod. While not rebuilt from the ground up, sweeping and extensive changes will be made. Making all of this happen will be no small feat, so I would like to take this opportunity to open things up to the community. I would like for this mod to turn into something made by a team. It would be great to have a team with diverse skills and ideas all contributing to it, rather than everything coming from the vortex that is my head. I am looking for talent in writing, level design, quest development, Papyrus, and 3D modelling. If you are interested in signing up, please fill out this form.
Here are some of the main things you can hope to expect:
A rewrite/revision + extension of the main story.
More focus will be spent on player choice and freedom, rather than a story involving you basically babysitting the chosen one. While Vala Amatius will still be a key part of the narrative, it will no longer be strictly centered around her. Additionally, this will no longer be a story that assumes you played through or remember the events that happened in Oblivion, but it will reward those of you that have/do.
It will dive into exploring the history of the Dark Brotherhood and how it got to the point where it is presently in the original Skyrim story. You, the player, will have first-hand experience figuring out what exactly happened, how to prevent it from ever happening again, and how you plan on rebuilding the Brotherhood. Will you recruit new assassins first? Will you have new Sanctuaries opened? Will you restore the Black Hand, or operate on your own? Will you drive it all into the ground? The choice will be yours. You as the Listener will take a more active and hands-on role in how everything plays out. The story will no longer force you in any one direction, and you will have choice and agency at every turn. The decisions you make will play a pivotal role in how the story plays out and subsequently ends. While the Night Mother will still offer you suggestions on what to do and where to go, the final decision will always rest in your hands.
There will be a handful of interesting and fleshed out characters for you to choose from when recruiting. You will have freedom to choose among the characters you like, and will no longer be forced into selecting the ones that the mod chooses for you.
Each character introduced, which will include existing ones like J’Zakar, M’Jirra, Undil, Azuk and of course, Vala, will all have “loyalty missions” similar to how it’s done in Mass Effect. For those of you who don’t know what that means… Essentially, you will have the option to talk to each of these characters about their backstories, which will lead to you going on a little personal adventure with them if you so choose. By the end of these loyalty quests, you will be able to take each of them as a follower and companion who will also be marriageable if you want that.
Who are we up against?
The Crimson Scars, who are the primary antagonist of this story, are an ancient splinter group of the Dark Brotherhood made up entirely of vampires. They believe that Sithis has ordered them to extinguish all non-vampires from the Dark Brotherhood and will stop at nothing to see this become a reality. In the original mod, they only show up near the tail end, and are basically shoe-horned in without much explanation. This will be changed in a big way. You will now encounter them much earlier on and they will be an active threat you experience throughout. Rumor has it that you may be able to join them, but that’s just hearsay. Subsequently, the Morag Tong will no longer be a part of this story and will be removed from it entirely unless there is a good reason for them to be involved.
New Sanctuary and location overhauls:
All of the new locations added by the mod will receive complete overhauls and will look far better than they do currently.
New items, weapons, and armors:
In addition to the bonus rewards you receive from quests, there will be new unique weapons and armors that any self-respecting Listener would enjoy.
So that’s basically it. It’s a very lofty and ambitious goal, but it is one I am committed to bringing to life. Again, if you are interested in helping me make this happen, please sign up by filling out this form.
Thanks for reading, Tom Tesoro

Super Protocol is building a decentralized network with confidential computing at its core (but you should probably know that if you’re a long-term Super follower). In the previous article, we covered how Testnet Phase Two enables this network to host websites with static content. While we’re gearing up for the next leap (which are dynamic applications using NextJS, by the way), there’s another thing that’s not often mentioned, yet imperative for the Super Protocol network to operate and be capable of supporting an unlimited number of applications, services, providers — basically, almost everything that could be found on the internet.
Have you already guessed what it is? And no, we’re not going to talk about high-scale architecture, data centers, or some other facilities typically mentioned in the context of the cloud. You’ve definitely heard the acronym DNS or the Domain Naming System. It’s not a super-hyped thing and usually mentions a spike in the media space when something goes wrong in a big way (like the infamous 2021 Facebook Outage, or the great internet outage earlier that year).
First, a quick refresher on DNS: we already got the “if something is wrong with it, the internet breaks”. In simple terms, DNS makes user-friendly website names possible, so you could enter ‘superprotocol.com’ instead of an abstract combination of numbers. A more complex definition would be DNS is a network service that maps IP addresses to human-readable names. This service is one of the backbones of the modern internet with few trusted providers responsible for most of the web traffic.
So why reinvent the fundamentals once again, while we’ve stated multiple times that it’s way better to reuse already available components? Turns out, having few providers for the networking service as important as DNS is not the best setup if you’re building an unstoppable web of the future. There was no ready-to-use alternative for us, so we went along with building our own.
The good thing about creating your own infrastructural service is having total control over how it’s going to work and the features it could provide. Another awesome thing is removing limitations you’d have with third-party providers, such as a limited number of domains, hosts, or subdomains you could have (for example, with [Cloudflare pages]). Having our own DNS would make the network more flexible and resilient, while also providing more options for its governance in the future.
Security at every level is one of the core ideas behind Super Protocol, so no surprise that with our own DNS, we’d be able to ensure advanced levels of protection, for example, prevent DNS Spoofing (a type of attack when a malicious actor uses a compromised DNS resolver machine to reroute the request to another website, or DNS hijacking which is similar in result, yet uses another type of vulnerability tempering with the resolver’s cache). Of course, traditional things required for a stable secure network, such as SSL certificates, will be added in the future (expected to be already implemented in Testnet Phase 3).
As for the upcoming features, we’re building DNS and components that would come with it and make the Super Protocol network truly decentralized and unstoppable (more on that in our upcoming updates).
https://preview.redd.it/huexwpjxhk4b1.png?width=828&format=png&auto=webp&s=ccac66299e64137d48ae44d886391a1fbcf87afe

Health is our greatest treasure and with incredible specialists. We all know that there is a better chance for a healthier population.
The government has established a massive number of health institutes or health caring centers in their countries so that people should not compromise when it comes to health.
Also Read: Top 10 Countries That Produce the Most Doctors
List Of Top 10 Doctors Around The World
Here is a list of the 10 best doctors in the world:

1. Dr. William A. Abdu, M.D, M.S.

Dr. Abdu is an Associate Professor of Orthopedics and of The Dartmouth Institute Medical Director at Dartmouth-Hitchcock Medical Center
Dr. Abdu got his accreditation in 1985 from Tufts University. He is a pioneer in the study and treatment of spine-related conditions. He hones surgery of the Spine, including Cervical, Thoracic and Lumbar Disorders, Disk Herniation, Spinal Stenosis, Spondylolisthesis, Spondylotic Myelopathy, Spinal Cord Injury, and Spine Trauma. Also, he had discovered many new techniques for spine treatment.

1. Dr. Myles. B. Abbott, M.D.

Dr. Myles is also one of the best-known doctors of Pediatricians in the world. He graduated from the University of Miami Leonard M Miller School of Medicine in 1972. He treats the problems of growth and child development.
Dr. Myles currently practices at East Bay Pediatric & Medical Group and is affiliated with Alta Bates Summit Medical Center Alta Bates Campus and Children’s Hospital & Research Center Oakland.

1. Dr. Fouad. M. Abbas, M.D.

Dr. Abbas is a well-known Gynecologist/Oncologist. His specialization field is Oncologist of Obstetrician and Gynecology. He is also considered to be one of the best doctors of Oncology in the world. The term Oncology is the study of cancer.
Dr. Abbas graduated from the University of Maryland School of Medicine in 1986. Currently, he is affiliated with Medstar Harbor Hospital and Sinai Hospital Of Baltimore.

1. Dr. Khalid Abbed, M.D.

Dr. Khalid is a famous doctor of Neuro. He is an Associate Professor and Chief of the Spine Section in the Department of Neurosurgery. His area of clinical interest is in the treatment of spinal disorders.
Dr. Khalid obtained his bachelor’s degree in Biological Sciences from the University of Illinois in Champaign-Urbana in 1993. He continued his education in the same University and received his Doctor of Medicine degree with Honors in 1999. Currently, he is working at Yale as a Director of the Spine Surgery Department. Many consider him the best doctor in the world.

1. Dr. Naresh Trehan

Dr. Naresh is a famous Indian cardiovascular and cardiothoracic surgeon. He was born on August 12, 1946, in Delhi, India. He obtained a medical degree from King George’s Medical College in Lucknow.
Dr. Naresh was also the founder, executive director, and chief cardiovascular surgeon of Escorts Heart Institute and Research Center (EHIRC), New Delhi, India. At present, he is serving as a Chairman and Managing Director and Chief Cardiac Surgeon of MedantaTM-The Medicity, one of the largest multi-specialty hospitals at Gurgaon, Haryana.

1. Dr. Arthur Reese Abright, M.D.

Dr. Reese is also one of the best doctors of Psychiatry. She treats the problems of depressions and mind-related problems.
Dr. Reese got her accreditation from The University of Texas Southwestern Medical School. She is also an expert on mood disorders and anxiety. Currently, she is working as a Professor of Psychiatry at Icahn School of Medicine at Mount Sinai. She is also affiliated with Mount Sinai Services Elmhurst Hospital Center and New York Medical College at present.

1. Dr. Corrie T.M Anderson, M.D.

Dr. Anderson is also one of the best doctors in Pediatric Anesthesiologist around the world. He received his A.B. with Honors in Biochemistry from Harvard University and Doctor of Medicine (M.D) from Stanford University School of Medicine in 1982. He can be truly crowned as “world best doctor”.
In 2001, Dr. Anderson became the director of the program for Pediatric Pain Medicine in the Department of Anesthesiology at Seattle Children’s Hospital. He is also a professor of anesthesiology and associate professor of pediatrics at the University of Washington School of Medicine.

1. Dr. Mark. F. Aaron, M.D.

Dr. Aaron is also one of the best doctors in cardiologists. His specialization is Cardiovascular Disease. The term Cardiology is related to the heart and its problems.
Dr. Aaron got his accreditation from the Duke University School of Medicine in 1992. Currently, he is affiliated with River Park Hospital, Saint Thomas West Hospital, and Henry County Medical Center.

1. Dr. Sudhansu Bhattacharyya, MBBS, MS, MCH

Dr. Sudhansu is also one of the best Indian Cardiovascular Surgeons. He obtained MBBS and M.S. General Surgery from Ahmedabad. He had invented, designed, and patented a few surgical instruments, the most important ones being Atrial Retractor for Mitral Valve Replacement and Internal Mammary Artery Retractor for taking down bilateral Internal Mammary Arteries.
Before entering into the practice world, Dr. Sudhansu served as a full-time Professor for Cardiothoracic surgery at Sheth G.S. Medical College & K.E.M. Hospital. At present, he is affiliated with Bombay Hospital And Medical Research Center, Breach Candy Hospital, Mumbai, and Lilavati Hospital & Research Center, Mumbai.
10. Dr.Mona.M.Abaza, M.D.
Dr. Abaza is a specialized doctor in ENT Otolaryngologist, Adenoidectomy, esophagoscopy, Nasal airway surgery, and tracheostomy. She is a world-famous ENT Doctor and treats problems of the ear, head, nose, throat, and neck.
Dr. Abaza graduated from the Medical College of Pennsylvania in 1991. She is affiliated with Children’s Hospital Colorado At Memorial Hospital Central and the University Of Colorado Hospital.
Conclusion
Since the dawn of time, the profession of a doctor is one of the most appreciated jobs in the world. Being a doctor implies a great responsibility, as almost every day the nature of somebody’s life (or the life itself) is in their hands. Since the medical field is a vast and ever-expanding field, there is no direct answer to who is the best doctor in the world. Doctors are specialized and trained in different field

Hi, I play as the Pope (formed Kingdom of God already) and I am curious what makes countries join reformation or stay catholic? How to prevent my allies or big countries (that I cannot convert easily to get rid of Center of Reformation) from reforming? Can I even? I am the curia controller, if it matters.